Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line.

نویسندگان

  • Flora Cimmino
  • Daniela Spano
  • Mario Capasso
  • Nicola Zambrano
  • Roberta Russo
  • Massimo Zollo
  • Achille Iolascon
چکیده

Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which G beta2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.

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عنوان ژورنال:
  • Journal of proteome research

دوره 6 7  شماره 

صفحات  -

تاریخ انتشار 2007